The Israeli military has struck the Syrian defence ministry in Damascus and the government forces in southern Syria in a deadly blow.
Syrian state media reported the loud explosions in the city, where at least three people were killed and 34 others were injured.
Since the clashes between Druze militias and Bedouin tribes erupted on Sunday, more than 300 people have been killed in Suweida.
Israeli Prime Minister Benjamin Netanyahu claimed his forces were "working to save our Druze brothers and to eliminate the regime's gangs" while the Syrian foreign ministry accused Israel of "treacherous aggression".
The U.S. has stepped into the conflict with Secretary of State Marco Rubio saying he was “very worried” about the violence in the south but believed it would end within hours.
“We have agreed on specific steps that will bring this troubling and horrifying situation to an end tonight,” he said.
“This will require all parties to deliver on the commitments they have made, and this is what we fully expect them to do.”
As the situation developed on Wednesday, Netanyahu was giving evidence in his corruption trial in a Tel Aviv courthouse and had to leave the stand.
In a video statement, he urged Israeli Druze not to cross the border.
"You are risking your lives: you can be murdered, you can be kidnapped, and you are harming the efforts of the IDF," he said.
"Therefore, I ask you — return to your homes, let the IDF operate."
The IDF announced it would "reinforce its forces" along the border with Syria, through the occupied Golan Heights.
"The IDF will continue to operate, both in defence and offence, to ensure the security of Israeli civilians," the IDF said in a statement.
United Nations Secretary General António Guterres has condemned Israel’s air strikes.
"The Secretary-General further condemns Israel's escalatory airstrikes on Suweida, Daraa, and in the centre of Damascus, as well as reports of the IDF's redeployment of forces in the Golan," Guterres's spokesman, Stephane Dujarric, said in a statement.
